Two of your ad sets — the 1% lookalike of purchasers, and the broad skincare interests set — are aimed at mostly the same people. 63% of the audience is in both.
What that means: every time one of those overlapping users could see an ad, Meta runs a mini-auction between your two ad sets. You're paying a premium to win an auction against yourself. The fix takes 30 seconds — add an exclusion in the secondary ad set so each user is only targeted by one.